Glycosyl compounds
Medchemexpress LLC 1-deazaadenosine | 14432-09-8 | MFCD22683837 | 98.9% | 266.25 | C11H14N4O4 | 1 MG
1-Deazaadenosine is a nucleoside analogue used as a biochemical research reagent that potently inhibits adenosine deaminase (ADA) and is used in in vitro studies of ADA-related pathways and lymphoproliferative disorders.
- Potent adenosine deaminase (ADA) inhibitor with Ki = 0.66 μM.
- High purity: 98.9%.
- Molecular weight: 266.25 g/mol.
- Chemical formula: C11H14N4O4.
- White to off-white solid suitable for laboratory use.
- Recommended storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years); in solvent at -80°C (up to 6 months) or -20°C (up to 1 month).
Apexbio Technology LLC 5-Azacytidine 320-67-2 1g
5-Azacytidine is a cytidine analog compound that functions as an inhibitor of DNA methyltransferase (DNMT) Its mechanism involves incorporation into cellular DNA/RNA followed by covalent binding to DNMT through the formation of a bond between the C6 position of 5-Azacytidine and the thiol group of cysteine residues in DNMT enzymes leading to reduced DNMT activity and subsequent DNA demethylation In cellular studies involving multiple myeloma (MM) 5-Azacytidine exhibits cytotoxicity against MM-derived cell lines (MM 1S MM 1R RPMI-8266 RPMI-LR5 RPMI-Dox40) with reported IC50 values of approximately 1 5 mol/L 0 7 mol/L 1 1 mol/L 2 5 mol/L and 3 2 mol/L respectively as well as patient-derived MM cells (IC50 1 5 mol/L) This compound is widely used in cancer research to investigate epigenetic regulation mechanisms and DNA methylation pathways
Chem-Impex International, Inc. 5-Azacytidine | 320-67-2 | MFCD00006539 | 1G
5-Azacytidine, 320-67-2, MFCD00006539, 1G
Apexbio Technology LLC 6-AZURIDINE-500MG
6-Azuridine (CAS No 54-25-1) is a nucleoside analog used in biomedical research particularly in antiviral and anticancer studies Originating from modifications of naturally occurring uridine it acts primarily by inhibiting nucleotide biosynthesis interfering with viral RNA replication and targeting pathways involved in cell proliferation Its in vitro activity is typically observed in the nanomolar to low micromolar range making it effective in disrupting viral ion channels and proliferation in cancer cell lines Common applications include use in cell culture models and animal studies to explore its therapeutic potential and to screen for new drugs Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC 5-Azacytidine 320-67-2 10mM (in 1mL DMSO)
5-Azacytidine is a cytidine analog compound that functions as an inhibitor of DNA methyltransferase (DNMT) Its mechanism involves incorporation into cellular DNA/RNA followed by covalent binding to DNMT through the formation of a bond between the C6 position of 5-Azacytidine and the thiol group of cysteine residues in DNMT enzymes leading to reduced DNMT activity and subsequent DNA demethylation In cellular studies involving multiple myeloma (MM) 5-Azacytidine exhibits cytotoxicity against MM-derived cell lines (MM 1S MM 1R RPMI-8266 RPMI-LR5 RPMI-Dox40) with reported IC50 values of approximately 1 5 mol/L 0 7 mol/L 1 1 mol/L 2 5 mol/L and 3 2 mol/L respectively as well as patient-derived MM cells (IC50 1 5 mol/L) This compound is widely used in cancer research to investigate epigenetic regulation mechanisms and DNA methylation pathways
Cayman Chemical 7-keto Cholesterol 5mg
A bioactive oxysterol; a major oxysterol component of oxidized LDL; produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by CYP7A1; inhibits CYP7A1 (IC50 = ~1 μM); induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state; increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye; levels are increased in lipid deposits in a variety of chronic diseases
Apexbio Technology LLC 3-Deazaadenosine(Synonyms: 3-Deazaadenosine, 3-Deaza-adenosine, 3DA, Cordycepin analog, Tubercidin), 1mg, CAS: 6736-58-9.
3-Deazaadenosine (CAS 6736-58-9) is an inhibitor of S-adenosylhomocysteine (SAH) hydrolase an enzyme responsible for the reversible hydrolysis of SAH into adenosine and homocysteine Inhibition of SAH hydrolase by 3-Deazaadenosine (Ki 3 9 M) elevates intracellular SAH concentrations altering the SAH-to-SAM (S-adenosylmethionine) ratio and consequently suppressing SAM-dependent methyltransferase activities In vitro studies demonstrate its antiviral activity against Ebola and Marburg viruses in various primate and mouse cell lines Animal studies indicate protective efficacy against lethal Ebola infection in BALB/c mice Currently 3-Deazaadenosine remains in preclinical research
Apexbio Technology LLC 3-Deazaadenosine hydrochloride(Synonyms: 3-Deazaadenosine HCl, C3-Deazaadenosine hydrochloride, 3-Deaza-adenosine hydrochloride), 1mg, CAS: 86583-19-9.
3-Deazaadenosine hydrochloride (CAS 86583-19-9) is a selective inhibitor of S-adenosylhomocysteine hydrolase (SAHH) exhibiting inhibition with a Ki value around 3 9 M It disrupts SAHH-dependent methyl metabolism pathways thereby altering intracellular methyltransferase reactions Due to this biochemical activity it serves as a research agent for studying inflammation cell proliferation and HIV infection as well as investigations into enzyme-mediated methylation processes and related pathological mechanisms
Apexbio Technology LLC 3-Deazaadenosine hydrochloride(Synonyms: 3-Deazaadenosine HCl, C3-Deazaadenosine hydrochloride, 3-Deaza-adenosine hydrochloride), 10mg, CAS: 86583-19-9.
3-Deazaadenosine hydrochloride (CAS 86583-19-9) is a selective inhibitor of S-adenosylhomocysteine hydrolase (SAHH) exhibiting inhibition with a Ki value around 3 9 M It disrupts SAHH-dependent methyl metabolism pathways thereby altering intracellular methyltransferase reactions Due to this biochemical activity it serves as a research agent for studying inflammation cell proliferation and HIV infection as well as investigations into enzyme-mediated methylation processes and related pathological mechanisms
Aobchem 1-(2 6-Difluoro-3-nitrophenyl)ethanone | ≥97% | CAS 91188-91-9 | C8H5F2NO3 | 250mg
1-(2 6-Difluoro-3-nitrophenyl)ethanone | ≥97% | CAS 91188-91-9 | C8H5F2NO3 | 250mg